L’elenco che segue contiene sia gli studi relativi alla disfunzione sessuale post retinoide sia parte della bibliografia scientifica relativa agli effetti avversi/biologici dei farmaci contenenti isotretinoina, tra cui anche quelli relativi alla sindrome dell’occhio secco.

  1. Stachelek, J., Zwaans, B. M. M., Shtein, R., & Peters, K. M. (2025). Insights into the peripheral nature of persistent sexual dysfunction associated with post-finasteride, post-SSRI and post-accutane syndromes: lessons learned from a case study. International urology and nephrology, 10.1007/s11255-025-04373-w. Advance online publication. https://doi.org/10.1007/s11255-025-04373-w
  2. Alajaji, A. N. (2024). Association Between Baseline Serum Lipids and Severity of Dry Eye Symptoms in Acne Patients Treated with Isotretinoin. Cureus. https://doi.org/10.7759/cureus.60922
  3. Herlihy, M., Beatty, P., & Field, S. (2024). P089 Counselling and monitoring for sexual dysfunction during treatment with isotretinoin: experience of Irish dermatologists. British Journal of Dermatology, 191(Supplement_1), i57–i57. https://doi.org/10.1093/bjd/ljae090.116
  4. Mitsaki, K. S., Chawla, S., & Merika, E. E. (2024). A retrospective review of isotretinoin treatment-related mental health and sexual function outcomes in a tertiary acne clinic. British Journal of Dermatology. https://doi.org/10.1093/bjd/ljae326
  5. AlHussein, M., & AlHussain, A. H. (2023). Ulcerative Colitis Flare Post Isotretinoin Use: A Case Report. Cureus. https://doi.org/10.7759/cureus.46429
  6. Ghadimi, T. R., Martinez, M., & Rieder, E. (2023). Self-Reported Long-Term Side Effects of Isotretinoin: A Case Series. Journal of Drugs in Dermatology, 22(4), 423–424. https://doi.org/10.36849/jdd.2303
  7. Hannah D. Pile , Nazia M. Sadiq. Isotretinoin (2023) PMID: 30247824 Bookshelf ID: NBK525949 https://www.ncbi.nlm.nih.gov/books/NBK525949/
  8. Lamberg, O., Strome, A., Jones, F., Mleczek, J., Jarocki, A., Troost, J. P., & Helfrich, Y. (2023). Ocular side effects of systemic isotretinoin – a systematic review and summary of case reports. Journal of Dermatological Treatment, 34(1). https://doi.org/10.1080/09546634.2023.2213364
  9. Acar Eser, N., Kocabeyoğlu, S., Atakan, N., & Irkec, M. (2022). The effects of the systemic isotretinoin treatment on ocular surface and meibomian glands: a prospective longitudinal study. Cutaneous and Ocular Toxicology, 41(2), 155–161. https://doi.org/10.1080/15569527.2022.2077749
  10. Gurlevik, U., Kemeriz, F., & Yasar, E. (2022). The effect of isotretinoin on meibomian glands in eyes: a pilot study. International Ophthalmology, 42(7), 2071–2078. https://doi.org/10.1007/s10792-021-02205-1
  11. Healy, D., Bahrick, A., Bak, M., Barbato, A., Calabrò, R. S., Chubak, B. M., Cosci, F., Csoka, A. B., D’Avanzo, B., Diviccaro, S., Giatti, S., Goldstein, I., Graf, H., Hellstrom, W. J. G., Irwig, M. S., Jannini, E. A., Janssen, P. K. C., Khera, M., Kumar, M. T., … Waraich, A. (2022). Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin. International Journal of Risk & Safety in Medicine, 33(1), 65–76. https://doi.org/10.3233/jrs-210023
  12. Bremner, J. D. (2021). Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed. Journal of Affective Disorders Reports, 6, 100230. https://doi.org/10.1016/j.jadr.2021.100230
  13. Tanriverdi, C., Nurozler Tabakci, B., & Donmez, S. (2021). Longitudinal assessment of meibomian glands and tear film layer in systemic isotretinoin treatment. European Journal of Ophthalmology, 32(2), 885–893. https://doi.org/10.1177/11206721211018361
  14. Gualtieri, B., Ingegneri, A., Chiricozzi, A., & Romanelli, M. (2020). Gynecomastia following isotretinoin treatment: a rare endocrine side effect. Giornale Italiano Di Dermatologia e Venereologia, 155(4). https://doi.org/10.23736/s0392-0488.18.06022-4
  15. Paredes-Bhushan, V., Rezaee, M. E., & Chavez, D. R. (2020). Isotretinoin induced urethritis: A case report & review of the literature. Urology Case Reports, 29, 101109. https://doi.org/10.1016/j.eucr.2019.101109
  16. Ruiz‐Lozano, R. E., Hernández‐Camarena, J. C., Garza‐Garza, L. A., Bustamante‐Arias, A., Colorado‐Zavala, M. F., & Cardenas‐de la Garza, J. A. (2020). Isotretinoin and the eye: A review for the dermatologist. Dermatologic Therapy, 33(6). Portico. https://doi.org/10.1111/dth.14029
  17. Ballout, R. A., & Maatouk, I. (2018). Isotretinoin-induced urethritis versus non-gonococcal urethritis in a man who has sex with men: an open debate. International Journal of STD & AIDS, 29(10), 1024–1026. https://doi.org/10.1177/0956462418761261
  18. Healy, D., Le Noury, J., & Mangin, D. (2018). Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases. International Journal of Risk & Safety in Medicine, 29(3–4), 125–134. https://doi.org/10.3233/jrs-180744
  19. Melnik, B. C. (2017). Overexpression of p53 explains isotretinoin’s teratogenicity. Experimental Dermatology, 27(1), 91–93. Portico. https://doi.org/10.1111/exd.13420
  20. Melnik, B. (2017). Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity. Acta Dermato Venereologica, 97(2), 173–181. https://doi.org/10.2340/00015555-2535
  21. Caglar, C., Senel, E., Sabancilar, E., & Durmus, M. (2016). Reduced ocular surface disease index (OSDI) scores in patients with isotretinoin treatment. International Ophthalmology, 37(1), 197–202. https://doi.org/10.1007/s10792-016-0263-y
  22. Stancil, S. L., Miller, M., Briggs, H., Lynch, D., Goggin, K., & Kearns, G. (2016). Contraceptive Provision to Adolescent Females Prescribed Teratogenic Medications. Pediatrics, 137(1). https://doi.org/10.1542/peds.2015-1454
  23. Moy, A., McNamara, N. A., & Lin, M. C. (2015). Effects of Isotretinoin on Meibomian Glands. Optometry and Vision Science, 92(9), 925–930. https://doi.org/10.1097/opx.0000000000000656
  24. Hogan, C., Le Noury, J., Healy, D., & Mangin, D. (2014). One hundred and twenty cases of enduring sexual dysfunction following treatment. International Journal of Risk & Safety in Medicine, 26(2), 109–116. https://doi.org/10.3233/jrs-140617
  25. Bremner, J. D., Shearer, K. D., & McCaffery, P. J. (2012). Retinoic acid and affective disorders: the evidence for an association. The Journal of clinical psychiatry, 73(1), 37–50. https://doi.org/10.4088/JCP.10r05993
  26. Ustun, I., Rifaioglu, E. N., Sen, B. B., Inam, M. U., & Gokce, C. (2012). Gynecomastia: a rare complication of isoretinoin? Cutaneous and Ocular Toxicology, 32(1), 93–94. https://doi.org/10.3109/15569527.2012.705406
  27. Griffin, J. N., Pinali, D., Olds, K., Lu, N., Appleby, L., Doan, L., & Lane, M. A. (2010). 13-Cis-retinoic acid decreases hypothalamic cell number in vitro. Neuroscience Research, 68(3), 185–190. https://doi.org/10.1016/j.neures.2010.08.003
  28. Liu, Y., Kagechika, H., Ishikawa, J., Hirano, H., Matsukuma, S., Tanaka, K., & Nakamura, S. (2008). Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons. Journal of Neurochemistry, 106(3), 1104–1116. Portico. https://doi.org/10.1111/j.1471-4159.2008.05445.x
  29. O’Reilly, K., Bailey, S. J., & Lane, M. A. (2008). Retinoid-Mediated Regulation of Mood: Possible Cellular Mechanisms. Experimental Biology and Medicine, 233(3), 251–258. https://doi.org/10.3181/0706-mr-158
  30. Bachmann, C., Grabarkiewicz, J., Theisen, F., & Remschmidt, H. (2007). Isotretinoin, Depression and Suicide Ideation in an Adolescent Boy. Pharmacopsychiatry, 40(3), 128–128. https://doi.org/10.1055/s-2007-972575
  31. O’Reilly, K. C., Trent, S., Bailey, S. J., & Lane, M. A. (2007). 13-cis-Retinoic Acid Alters Intracellular Serotonin, Increases 5-HT1AReceptor, and Serotonin Reuptake Transporter LevelsIn Vitro. Experimental Biology and Medicine, 232(9), 1195–1203. https://doi.org/10.3181/0703-rm-83
  32. O’Reilly, K. C., Shumake, J., Gonzalez-Lima, F., Lane, M. A., & Bailey, S. J. (2006). Chronic Administration of 13-Cis-Retinoic Acid Increases Depression-Related Behavior in Mice. Neuropsychopharmacology, 31(9), 1919–1927. https://doi.org/10.1038/sj.npp.1300998
  33. Reddy, D., Siegel, C. A., Sands, B. E., & Kane, S. (2006). Possible Association Between Isotretinoin and Inflammatory Bowel Disease. The American Journal of Gastroenterology, 101(7), 1569–1573. https://doi.org/10.1111/j.1572-0241.2006.00632.x
  34. Tirado Sánchez, A., & León Dorantes, G. (2005). Disfunción eréctil durante el tratamiento con isotretinoína. Actas Urológicas Españolas, 29(10), 974–976. https://doi.org/10.1016/s0210-4806(05)73379-9
  35. Fraunfelder, F.W. (2004). Ocular side effects associated with isotretinoin. Drugs of Today, 40(1), 23. https://doi.org/10.1358/dot.2004.40.1.799435
  36. Does isotretinoin cause depression and suicide? (2003) J Douglas Bremner https://pubmed.ncbi.nlm.nih.gov/14561949/
  37. Prokop, L. D. (1999). Isotretinoin: Possible Component Cause of Inflammatory Bowel Disease. American Journal of Gastroenterology, 94(9), 2568. https://doi.org/10.1111/j.1572-0241.1999.02568.x
  38. Lerman S. (1992). Ocular side effects of accutane therapy. Lens and eye toxicity research, 9(3-4), 429–438. https://pubmed.ncbi.nlm.nih.gov/1301795/
  39. Fraunfelder, F. T., LaBraico, J. M., & Meyer, S. M. (1985). Adverse Ocular Reactions Possibly Associated With Isotretinoin. American Journal of Ophthalmology, 100(4), 534–537. https://doi.org/10.1016/0002-9394(85)90676-2