Una bibliografia scientifica sulla disfunzione sessuale post-SSRI aggiornata al 5 novembre 2024. L’elenco che segue contiene anche alcuni studi atti ad elucidare i meccanismi alla base della sindrome.

  1. Stachelek, J., Zwaans, B. M. M., Shtein, R., & Peters, K. M. (2025). Insights into the peripheral nature of persistent sexual dysfunction associated with post-finasteride, post-SSRI and post-accutane syndromes: lessons learned from a case study. International urology and nephrology, 10.1007/s11255-025-04373-w. Advance online publication. https://doi.org/10.1007/s11255-025-04373-w
  2. Giatti, S., Cioffi, L., Diviccaro, S., Chrostek, G., Piazza, R., & Melcangi, R. C. (2024). Transcriptomic Profile of the Male Rat Hypothalamus and Nucleus Accumbens After Paroxetine Treatment and Withdrawal: Possible Causes of Sexual Dysfunction. Molecular Neurobiology. https://doi.org/10.1007/s12035-024-04592-9
  3. Giatti, S., Diviccaro, S., Cioffi, L., & Cosimo Melcangi, R. (2024). Post-Finasteride Syndrome And Post-Ssri Sexual Dysfunction: Two Clinical Conditions Apparently Distant, But Very Close. Frontiers in Neuroendocrinology, 72, 101114. https://doi.org/10.1016/j.yfrne.2023.101114
  4. Healy, D., & Mangin, D. (2024). Post-SSRI sexual dysfunction: barriers to quantifying incidence and prevalence. Epidemiology and Psychiatric Sciences, 33. https://doi.org/10.1017/s2045796024000441
  5. Naguy, A., & Alamiri, B. (2024). Selective Serotonin Reuptake Inhibitor–Related Tardy Sexual Dysfunction. The Primary Care Companion For CNS Disorders, 26(3). https://doi.org/10.4088/pcc.23lr03697
  6. Pirani, Y., Delgado-Ron, J. A., Marinho, P., Gupta, A., Grey, E., Watt, S., MacKinnon, K. R., & Salway, T. (2024). Frequency of self-reported persistent post-treatment genital hypoesthesia among past antidepressant users: a cross-sectional survey of sexual and gender minority youth in Canada and the US. Social Psychiatry and Psychiatric Epidemiology. https://doi.org/10.1007/s00127-024-02769-0
  7. Beltrame, F. L., Moysés, T. H. P., Coelho, M. P., Steinvascher, M. C. R., de Oliveira, S. A., da Silva, A. A. S., Cerri, P. S., & Sasso‐Cerri, E. (2023). Role of serotonin, estrogen, and TNF‐α in the paroxetine‐impaired steroidogenesis and testicular macrophages polarization. Andrology. Portico. https://doi.org/10.1111/andr.13513
  8. Ben-Sheetrit, J., Hermon, Y., Birkenfeld, S., Gutman, Y., Csoka, A. B., & Toren, P. (2023). Estimating the risk of irreversible post-SSRI sexual dysfunction (PSSD) due to serotonergic antidepressants. Annals of General Psychiatry, 22(1). https://doi.org/10.1186/s12991-023-00447-0
  9. Gül, M., Fode, M., Urkmez, A., Capogrosso, P., Falcone, M., Sarikaya, S., Sokolakis, I., Morgado, A., Morozov, A., Albersen, M., Russo, G. I., & Serefoglu, E. C. (2023). A clinical guide to rare male sexual disorders. Nature Reviews Urology. https://doi.org/10.1038/s41585-023-00803-5
  10. Klaas, S., Siva, J. B., Bak, M., Govers, M., & Schreiber, R. (2023). The pathophysiology of Post SSRI Sexual Dysfunction – Lessons from a case study. Biomedicine & Pharmacotherapy, 161, 114166. https://doi.org/10.1016/j.biopha.2022.114166
  11. Marks, S. (2023). A clinical review of antidepressants, their sexual side-effects, post-SSRI sexual dysfunction, and serotonin syndrome. British Journal of Nursing, 32(14), 678–682. https://doi.org/10.12968/bjon.2023.32.14.678
  12. Panek, E., Jasłowski, D., Rzeszutko, M., Raczkiewicz, P., Panasiuk, D., Skrętowicz, M., Szponarowicz, P., Snopkowski, B., Korzec, T., & Sosnowski, J. (2023). Post-SSRI sexual dysfunction and SSRI induced sexual dysfunction – literature review. Journal of Education, Health and Sport, 19(1), 64–72. https://doi.org/10.12775/jehs.2023.19.01.007
  13. Achour, V., Masson, M., Lancon, C., Boyer, L., & Fond, G. (2022). Screening and treatment of Post-Selective Serotonin Reuptake Inhibitors sexual dysfunctions. L’Encéphale, 48(6), 599–600. https://doi.org/10.1016/j.encep.2022.07.001
  14. De Luca, R., Bonanno, M., Manuli, A., & Calabrò, R. S. (2022). Cutting the First Turf to Heal Post-SSRI Sexual Dysfunction: A Male Retrospective Cohort Study. Medicines, 9(9), 45. https://doi.org/10.3390/medicines9090045
  15. Diviccaro, S., Giatti, S., Cioffi, L., Falvo, E., Piazza, R., Caruso, D., & Melcangi, R. C. (2022). Paroxetine effects in adult male rat colon: Focus on gut steroidogenesis and microbiota. Psychoneuroendocrinology, 143, 105828. https://doi.org/10.1016/j.psyneuen.2022.105828
  16. Lentacker, A. (2022). Epistemology of the side effect: anecdote and evidence in the digital age. BioSocieties. https://doi.org/10.1057/s41292-022-00293-5
  17. Post-Selective Serotonin Reuptake Inhibitor Sexual Dysfunctions(PSSD): Clinical Experience with a Multimodal Approach. (2022). Journal of Men’s Health, 18(8), 1. https://doi.org/10.31083/j.jomh1808165
  18. Reisman, Y., Pfaus, J. G., & Lowenstein, L. (2022). Post-SSRI Sexual Dysfunction (PSSD). Textbook of Rare Sexual Medicine Conditions, 51–63. https://doi.org/10.1007/978-3-030-98263-8_5
  19. Chinchilla Alfaro, K., van Hunsel, F., & Ekhart, C. (2021). Persistent sexual dysfunction after SSRI withdrawal: a scoping review and presentation of 86 cases from the Netherlands. Expert Opinion on Drug Safety, 21(4), 553–561. https://doi.org/10.1080/14740338.2022.2007883
  20. Giatti, S., Diviccaro, S., Cioffi, L., Falvo, E., Caruso, D., & Melcangi, R. C. (2021). Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis. Psychoneuroendocrinology, 132, 105364. https://doi.org/10.1016/j.psyneuen.2021.105364
  21. Healy, D., Bahrick, A., Bak, M., Barbato, A., Calabrò, R. S., Chubak, B. M., Cosci, F., Csoka, A. B., D’Avanzo, B., Diviccaro, S., Giatti, S., Goldstein, I., Graf, H., Hellstrom, W. J. G., Irwig, M. S., Jannini, E. A., Janssen, P. K. C., Khera, M., Kumar, M. T., … Waraich, A. (2022). Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin. International Journal of Risk & Safety in Medicine, 33(1), 65–76. https://doi.org/10.3233/jrs-210023
  22. Lew-Starowicz, M., Giraldi, A., & Krüger, T. H. C. (Eds.). (2021). Psychiatry and Sexual Medicine. Springer International Publishing. https://doi.org/10.1007/978-3-030-52298-8
  23. Patacchini, A., & Cosci, F. (2021). Exposure to serotonin selective reuptake inhibitors or serotonin noradrenaline reuptake inhibitors and sexual dysfunction: Results from an online survey. International Journal of Risk & Safety in Medicine, 32(3), 229–242. https://doi.org/10.3233/jrs-200074
  24. Studt, A., Gannon, M., Orzel, J., Vaughan, A., & Pearlman, A. M. (2021). Characterizing post-SSRI sexual dysfunction and its impact on quality of life through an international online survey. International Journal of Risk & Safety in Medicine, 32(4), 321–329. https://doi.org/10.3233/jrs-210039
  25. Waraich, A., Yih, J., Goldstein, S., & Goldstein, I. (2021). 076 Post-SSRI Sexual Dysfunction (PSSD): Ten Year Retrospective Chart Review. The Journal of Sexual Medicine, 18(Supplement_1), S41–S41. https://doi.org/10.1016/j.jsxm.2021.01.046
  26. Healy, D., LaPalme, J., & Levin, M. (2020). Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism? Bioelectricity, 2(1), 7–13. https://doi.org/10.1089/bioe.2019.0010
  27. Healy, D. (2020). Antidepressants and sexual dysfunction: a history. Journal of the Royal Society of Medicine, 113(4), 133–135. https://doi.org/10.1177/0141076819899299
  28. Lorenz, T. K. (2020). Antidepressant Use During Development May Impair Women’s Sexual Desire in Adulthood. The Journal of Sexual Medicine, 17(3), 470–476. https://doi.org/10.1016/j.jsxm.2019.12.012
  29. Reisman, Y. (2020). Post-SSRI sexual dysfunction. BMJ, m754. https://doi.org/10.1136/bmj.m754
  30. Rothmore, J. (2020). Antidepressant‐induced sexual dysfunction. Medical Journal of Australia, 212(7), 329–334. Portico. https://doi.org/10.5694/mja2.50522
  31. Healy, D., Le Noury, J., & Mangin, D. (2019). Post-SSRI sexual dysfunction: Patient experiences of engagement with healthcare professionals. International Journal of Risk & Safety in Medicine, 30(3), 167–178. https://doi.org/10.3233/jrs-191005
  32. Calabrò, R. S., De Luca, R., Manuli, A., Portaro, S., Naro, A., & Quattrini, F. (2019). Towards Improving Post-SSRI Sexual Dysfunction by Using Nutriceuticals: Lessons from a Case Study. Journal of Sex & Marital Therapy, 45(6), 562–565. https://doi.org/10.1080/0092623x.2018.1556755
  33. Healy, D. (2019). Post-SSRI sexual dysfunction & other enduring sexual dysfunctions. Epidemiology and Psychiatric Sciences, 29. https://doi.org/10.1017/s2045796019000519
  34. Patacchini, A., & Cosci, F. (2019). A Paradigmatic Case of Postselective Serotonin Reuptake Inhibitors Sexual Dysfunction or Withdrawal After Discontinuation of Selective Serotonin Reuptake Inhibitors? Journal of Clinical Psychopharmacology, 40(1), 93–95. https://doi.org/10.1097/jcp.0000000000001154
  35. Reisman, Y. (2019). Are There Any Sex/Gender Differences in Post-Selective Serotonin Reuptake Inhibitors (SSRI) Sexual Dysfunction (PSDD)? Current Sexual Health Reports, 11(4), 237–242. https://doi.org/10.1007/s11930-019-00222-x
  36. Bala, A., Nguyen, H. M. T., & Hellstrom, W. J. G. (2018). Post-SSRI Sexual Dysfunction: A Literature Review. Sexual Medicine Reviews, 6(1), 29–34. https://doi.org/10.1016/j.sxmr.2017.07.002
  37. Coskuner, E. R., Culha, M. G., Ozkan, B., & Kaleagasi, E. O. (2018). Post-SSRI Sexual Dysfunction: Preclinical to Clinical. Is It Fact or Fiction? Sexual Medicine Reviews, 6(2), 217–223. https://doi.org/10.1016/j.sxmr.2017.11.004
  38. Giatti, S., Diviccaro, S., Panzica, G., & Melcangi, R. C. (2018). Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin? Endocrine, 61(2), 180–193. https://doi.org/10.1007/s12020-018-1593-5
  39. Healy, D., Le Noury, J., & Mangin, D. (2018). Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases. International Journal of Risk & Safety in Medicine, 29(3–4), 125–134. https://doi.org/10.3233/jrs-180744
  40. Healy, D. (2018). Citizen petition: Sexual side effects of SSRIs and SNRIs. International Journal of Risk & Safety in Medicine, 29(3–4), 135–147. https://doi.org/10.3233/jrs-180745
  41. Muquebil Ali Al Shaban Rodríguez, O. W., Álvarez de Morales Gómez-Moreno, E., Fernández Fernández, J., Fresno García, C., & Fernández Fernández, M. del M. (2017). Disfunción sexual persistente tras el tratamiento con inhibidores selectivos de la recaptación de serotonina: a propósito de un caso tras la retirada de paroxetina. Psiquiatría Biológica, 24(2), 70–72. https://doi.org/10.1016/j.psiq.2017.05.004
  42. Reisman, Y. (2017). Sexual Consequences of Post-SSRI Syndrome. Sexual Medicine Reviews, 5(4), 429–433. https://doi.org/10.1016/j.sxmr.2017.05.002
  43. Simonsen, A. L., Danborg, P. B., & Gøtzsche, P. C. (2016). Persistent sexual dysfunction after early exposure to SSRIs: Systematic review of animal studies. International Journal of Risk & Safety in Medicine, 28(1), 1–12. https://doi.org/10.3233/jrs-160668
  44. Ben-Sheetrit, J., Aizenberg, D., Csoka, A. B., Weizman, A., & Hermesh, H. (2015). Post-SSRI Sexual Dysfunction. Journal of Clinical Psychopharmacology, 35(3), 273–278. https://doi.org/10.1097/jcp.0000000000000300
  45. Waldinger, M. D., van Coevorden, R. S., Schweitzer, D. H., & Georgiadis, J. (2015). Penile anesthesia in Post SSRI Sexual Dysfunction (PSSD) responds to low-power laser irradiation: A case study and hypothesis about the role of transient receptor potential (TRP) ion channels. European Journal of Pharmacology, 753, 263–268. https://doi.org/10.1016/j.ejphar.2014.11.031
  46. Hogan, C., Le Noury, J., Healy, D., & Mangin, D. (2014). One hundred and twenty cases of enduring sexual dysfunction following treatment. International Journal of Risk & Safety in Medicine, 26(2), 109–116. https://doi.org/10.3233/jrs-140617
  47. Farnsworth, K. D., & Dinsmore, W. W. (2009). Persistent sexual dysfunction in genitourinary medicine clinic attendees induced by selective serotonin reuptake inhibitors. International Journal of STD & AIDS, 20(1), 68–69. https://doi.org/10.1258/ijsa.2008.008402
  48. Bahrick, A. S., & Harris, M. M. (2008). Sexual Side Effects of Antidepressant Medications: An Informed Consent Accountability Gap. Journal of Contemporary Psychotherapy, 39(2), 135–143. https://doi.org/10.1007/s10879-008-9094-0
  49. Bahrick, A. S. (2008). Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications: Emerging Evidence. The Open Psychology Journal, 1(1), 42–50. https://doi.org/10.2174/1874350100801010042
  50. Csoka, A., Bahrick, A., & Mehtonen, O.-P. (2008). Persistent Sexual Dysfunction after Discontinuation of Selective Serotonin Reuptake Inhibitors. The Journal of Sexual Medicine, 5(1), 227–233. https://doi.org/10.1111/j.1743-6109.2007.00630.x
  51. Kauffman, R. P., & Murdock, A. (2007). Prolonged Post-Treatment Genital Anesthesia and Sexual Dysfunction Following Discontinuation of Citalopram and the Atypical Antidepressant Nefazodone. The Open Women’s Health Journal, 1(1), 1–3. https://doi.org/10.2174/1874291200701010001
  52. Bahrick, A. S. (2006). Post SSRI sexual dysfunction. American Society for the Advancement of Pharmacotherapy Tablet, 7(3), 2-3. https://www.researchgate.net/publication/236587031_Post_SSRI_Sexual_Dysfunction
  53. Csoka, A. B., & Shipko, S. (2006). Persistent Sexual Side Effects after SSRI Discontinuation. Psychotherapy and Psychosomatics, 75(3), 187–188. Portico. https://doi.org/10.1159/000091777
  54. Bolton, J. M., Sareen, J., & Reiss, J. P. (2006). Genital Anaesthesia Persisting Six Years after Sertraline Discontinuation. Journal of Sex & Marital Therapy, 32(4), 327–330. https://doi.org/10.1080/00926230600666410